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Research and Medications

This information has been gathered by The Cleft Lip & Palate Foundation of Smiles in response to the fact that a number of our members have questions concerning the safety of medications that they had taken during pregnancy or may take during a future pregnancy and the possible causes of cranial facial differences. Our goal is to ensure that our families have resources and facts about the medications that women maybe taking during pregnancy so that they can have informed discussions with the treating doctors.


The use of pharmaceutical medications can play a role in causing birth defects. This PDF is intended to inform women of childbearing-age about these factors.Download this PDF about birth defect risks for women who get pregnant.

This PDF discusses the use of Topamax for childbearing-age women. It raises difficult questions of evaluating the risks vs. the benefits.
Download this PDF about Topamax birth defect risks.

This PDF outlines some of the more common birth defects from the more well known brands of SSRIs.
Download this PDF about taking SSRIs during pregnancy.

This PDF is about Hydrocodone birth defect risks for women who get pregnant while taking this type of pain medication.
Download this PDF about birth defect risks of Hydrocodone.

This PDF is about Clomid, a non-steroidal fertility treatment used to induce ovulation in women who have difficulty conceiving.
Download this PDF about birth defect risks of Clomid.

In August 2011, the FDA issued a drug safety warning that long-term use of fluconazole during the first trimester of pregnancy may be associated with birth defects.
Download this PDF about birth defect risks of fluconazole.

This PDF is about Depakote valproate birth defect risks for women who get pregnant while taking this type of medication. Download this PDF about birth defect risks of Depakote.

This PDF is about Qsymia is a prescription weight loss medicine and a pregnancy category x drug. According to the drug’s website, “if you take Qsymia while you are pregnant, your baby has a higher risk for cleft lip and cleft palate”. Download this PDF about birth defect risks of Qsymia.
cleft palate and zofran
This PDF outlines information about Zofran (Generic: Ondansetron), a popular morning sickness drug, and a recent study which concluded there was a 2.37 times increased risk of cleft palate if the drug was taken during the first trimester. Download this PDF about birth defect risks of Zofran (Ondansetron).

Still have questions about the FDA's Recent Studies?

If you would like more information about the FDA studies, please contact us and one of our board members will be in contact to answer your questions and see if we can connect you with others who can help.

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Site last updated December 5, 2016 @ 3:07 pm; This content last updated April 21, 2015 @ 3:49 pm